Freeze drying

DFG Project with Technical University Munich (2019-2022)

Freeze drying is a very gentle method to conserve highly valuable products, such as from the food or pharmaceutical industry. It is a very slow process with strong capacity limitations. In the running project we study the pore scale effects of freeze drying and their impact on the evolution of the sublimation front, drying time, overall energy consumption and product quality. In parallel to pore network simulations and experiments with lymicroscopy (at TU Munich) we conduct measurements with neutron radiography and tomography at FRM-II (Heinz-Maier-Leibnitz Center, Garching/Germany) and at Paul Scherrer Institute (Villigen/Switzerland).

Relevant Publications:

1.            Vorhauer, N.; Först, P.; Schuchmann, H.; Tsotsas, E. (2018), Pore network model of primary freeze drying, Proceedings of the 21st International Drying Symposium (IDS2018), Valencia, Spain

2.            Först, P.; Lechner, M.; Vorhauer, N.; Schuchmann, H.; Tsotsas, E. (2018), Experimental investigations on pore size distribution and drying kinetics during lyophilization of sugar solutions, Proceedings of the 21st International Drying Symposium (IDS2018), Valencia, Spain

3.            Vorhauer, N., Kürschner, D., Först, P., Tsotsas, E. (2019) Characterization of primary lyophilization using a coulometrically based humidity sensor, Partec, Nürnberg, Germany

4.            Först, P.; Gruber, S.; Hilmer, M.; Vorhauer, N.; Schulz, M.; Tsotsas, E. (2019) Freeze drying behavior of spray frozen and pelletized materials by neutron radiography and tomography, Proceedings of the European Drying Conference (EuroDrying 2019), Torino, Italy

5.            Gruber, S.; Vorhauer, N.; Schulz, M.; Hilmer, M.; Peters, J.; Tsotsas, E.; Först, P. (2019) Estimation of the local sublimation front velocities from neutron radiography and tomography of particulate matter, Chemical Engineering Sciences, DOI: https://doi.org/10.1016/j.ces.2019.115268

6.            Först, P.; Gruber, S.; Schulz, M.; Vorhauer, N.; Tsotsas, E. (2019) Characterization of lyophilization of frozen bulky solids, submitted to Chemical Engineering Technology

7.            Hilmer, M., Gruber, S., Vorhauer, N., Schulz, M., Peters, J., Kürschner, D., Tsotsas, E., Först, P. (2019) Development of an experimental setup for in-situ visualization of the lyophilization using neutron radiography and computed tomography, submitted to Review of Scientifique instruments

8.            Vorhauer, N.; Siekmann, P.; Gruber, S.; Hilmer, M.; Mannes, D.; Thomik, M.; Tsotsas, E.; Först, P. (2019) Visualization of sublimation fingering using neutron tomography, submitted to Chemical Engineering Sciences

9.            Vorhauer, N.; Kürschner, D.; Tsotsas, E.; Först, P. Feasibility study of coulometrically based end point detection of primary freeze drying, to be submitted to Drying Technology (2019)

Letzte Änderung: 12.03.2020 - Ansprechpartner: Webmaster